Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78396 | 0.89 | MAPT (0.48) | MAPTKMT2ACYP2C9PTPN5NPC1 | |
| SCHEMBL29658872 | 0.84 | ADAMTS4 (0.40) | MAPTKMT2ACYP2C9PTPN5AKT1 | |
| SCHEMBL112703 | 0.79 | MAPT (0.55) | MAPTKMT2AALDH1A1ALOX15KIF11 | |
| SCHEMBL20741189 | 0.79 | MAPT (0.38) | MAPTKMT2ACYP2C9PTPN5AKT1 | |
| SCHEMBL3290659 | 0.77 | CYP2C9 (0.47) | MAPTKMT2ACYP2C9PTPN5NPC1 | |
| SCHEMBL22323537 | 0.76 | RXRA (0.50) | MAPTKMT2APTPN5DHODHALDH1A1 | |
| SCHEMBL4070722 | 0.75 | CYP2C9 (0.48) | MAPTKMT2ACYP2C9PTPN5NPC1 | |
| Propane SCHEMBL28558464 | 0.75 | MAPT (0.50) | MAPTKMT2ALMNAALDH1A1ALOX15 | |
| SCHEMBL80733 | 0.74 | LMNA (0.35) | LMNAALOX15 | |
| SCHEMBL13839048 | 0.73 | CYP2C9 (0.47) | MAPTKMT2ACYP2C9PTPN5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12491251-B2 | Degraders of cyclin-dependent kinase 7 (CDK7) and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2025-12-09 | — | — | US | disclosed |
| EP-4010336-B1 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2025-04-02 | — | — | EP | disclosed |
| US-20220280649-A1 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-09-08 | — | — | US | disclosed |
| US-10870651-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190055248-A1 | INHIBITORS OF CYCLINDEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. | 2019-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220280649-A1 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) AND USES THEREOF | CDK7, CDK8, CDK17 | MAPT 1671/4885KMT2A 779/4885CYP2C9 2096/4885 |
| US-12491251-B2 | Degraders of cyclin-dependent kinase 7 (CDK7) and uses thereof | CDK7, CDK8, CDK17 | MAPT 1671/4885KMT2A 779/4885CYP2C9 2096/4885 |
| US-20190055248-A1 | INHIBITORS OF CYCLINDEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | MAPT 172/4885KMT2A 886/4885CYP2C9 687/4885 |
| US-10870651-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | CDK7, CDK3, CDK9 | MAPT 265/4885KMT2A 1373/4885CYP2C9 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.