Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 15/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20741612 | 0.84 | TDP1 (0.58) | TDP1SMN1; SMN2MAPK1TSHRTP53 | |
| SCHEMBL3241977 | 0.82 | MAPK1 (0.60) | TDP1SMN1; SMN2MAPK1TSHRTP53 | |
| SCHEMBL28394365 | 0.82 | SLC6A3 (0.47) | TDP1SMN1; SMN2TSHRMAPTRAB9A | |
| SCHEMBL28389531 | 0.78 | MAPT (0.45) | TDP1SMN1; SMN2MAPK1MAPTL3MBTL1 | |
| SCHEMBL14130179 | 0.78 | TDP1 (0.51) | TDP1SMN1; SMN2MAPK1TSHRTP53 | |
| SCHEMBL14130412 | 0.78 | TP53 (0.51) | TDP1SMN1; SMN2MAPK1TSHRTP53 | |
| SCHEMBL12589874 | 0.77 | KDM4E (0.46) | TDP1SMN1; SMN2MAPTL3MBTL1RAB9A | |
| SCHEMBL14130411 | 0.76 | SMN1; SMN2 (0.49) | TDP1SMN1; SMN2MAPK1TSHRTP53 | |
| SCHEMBL14130404 | 0.75 | AHR (0.66) | TDP1SMN1; SMN2MAPK1TSHRTP53 | |
| SCHEMBL14130007 | 0.75 | AHR (0.66) | TDP1SMN1; SMN2MAPK1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11555026-B2 | AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2023-01-17 | — | — | US | disclosed |
| US-20210017153-A1 | AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2021-01-21 | — | — | US | disclosed |
| US-20210017153-A1 | AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2021-01-21 | — | — | US | disclosed |
| US-10696650-B2 | AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2020-06-30 | — | — | US | disclosed |
| US-10696650-B2 | AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190055218-A1 | AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2019-02-21 | — | — | US | disclosed |
| US-20190055218-A1 | AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2019-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11555026-B2 | AHR inhibitors and uses thereof | AHR, ARNT, AIPL1 | TDP1 3458/4885SMN1; SMN2 4882/4885MAPK1 2454/4885 |
| US-20210017153-A1 | AHR INHIBITORS AND USES THEREOF | AHR, ARNT, AIPL1 | TDP1 3458/4885SMN1; SMN2 4882/4885MAPK1 2454/4885 |
| US-10696650-B2 | AHR inhibitors and uses thereof | AHR, ARNT, AIPL1 | TDP1 3458/4885SMN1; SMN2 4882/4885MAPK1 2454/4885 |
| US-20190055218-A1 | AHR INHIBITORS AND USES THEREOF | AHR, ARNT, AIPL1 | TDP1 3458/4885SMN1; SMN2 4882/4885MAPK1 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.