SCHEMBL20744271

SCHEMBL20744271

COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)c2ccc(=O)n(C(C)C)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TAS2R14 Q9NYV8 13/20 0.54
CXCR3 P49682 2/20 0.51
PTGES O14684 1/20 0.51
TAS2R8 Q9NYW2 1/20 0.51
CNR1 P21554 1/20 0.50
CNR2 P34972 1/20 0.50
MAPT P10636 1/20 0.49
PKM P14618 1/20 0.49
APLNR P35414 1/20 0.49
LMNA P02545 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ALDH1A1 P00352 1/20 0.46
TSHR P16473 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20635816 0.85 TAS2R14 (0.48) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL22802347 0.84 MAPT (0.58) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL20635208 0.82 TAS2R14 (0.55) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL22408730 0.81 TAS2R14 (0.53) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL20635115 0.81 TAS2R14 (0.53) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL20609757 0.81 APLNR (0.49) TAS2R14CXCR3PTGESTAS2R8MAPT
SCHEMBL20635117 0.79 TAS2R14 (0.55) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL20634456 0.79 TAS2R14 (0.52) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL23272175 0.78 APLNR (0.49) TAS2R14CXCR3PTGESTAS2R8CNR1
SCHEMBL20634455 0.78 TAS2R14 (0.51) TAS2R14CXCR3PTGESTAS2R8CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115591-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2025-04-10 US disclosed
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors INFLAZOME LIMITED (IE) 2024-07-09 US disclosed
US-11981667-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2024-05-14 US disclosed
CN-111132974-B Sulfonamide carboxamide compounds 英夫拉索姆有限公司 2023-11-21 CN disclosed
US-20230037255-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2023-02-02 US disclosed
US-11465992-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2022-10-11 US disclosed
EP-3978489-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS Inflazome Limited (IE) 2022-04-06 EP disclosed
EP-3661925-B1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LTD (IE) 2021-11-24 EP disclosed
US-20210002274-A1 NOVEL COMPOUNDS INFLAZOME LIMITED (IE) 2021-01-07 US disclosed
US-20210002274-A1 NOVEL COMPOUNDS INFLAZOME LIMITED (IE) 2021-01-07 US disclosed
US-20200399242-A1 NOVEL COMPOUNDS INFLAZOME LIMITED (IE) 2020-12-24 US disclosed
US-20200399242-A1 NOVEL COMPOUNDS INFLAZOME LIMITED (IE) 2020-12-24 US disclosed
US-20200361895-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2020-11-19 US disclosed
US-20200291003-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS SYGNATURE DISCOVERY LIMITED (GB) 2020-09-17 US disclosed
EP-3668861-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS Inflazome Limited (IE) 2020-06-24 EP disclosed
WO-2019034686-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS INFLAZOME LIMITED (IE) 2019-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030879-B2 Sulfonyl acetamides as NLRP3 inhibitors NLRP3, NOD1, NLRP1 TAS2R14 732/4885CXCR3 719/4885PTGES 2455/4885
US-20200361895-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 TAS2R14 1601/4885CXCR3 936/4885PTGES 2073/4885
US-11981667-B2 Sulfonamide carboxamide compounds NLRP3, NOD1, PYCARD TAS2R14 812/4885CXCR3 1258/4885PTGES 1965/4885
US-20250115591-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 TAS2R14 688/4885CXCR3 1088/4885PTGES 2435/4885
US-20210002274-A1 NOVEL COMPOUNDS NLRP3, NOD1, NLRP1 TAS2R14 1339/4885CXCR3 249/4885PTGES 2032/4885
US-20200291003-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 TAS2R14 688/4885CXCR3 1088/4885PTGES 2435/4885
US-20200399242-A1 NOVEL COMPOUNDS NLRP3, NOD1, NLRP1 TAS2R14 896/4885CXCR3 429/4885PTGES 1281/4885
US-20230037255-A1 NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS NLRP3, NOD1, NLRP1 TAS2R14 722/4885CXCR3 1113/4885PTGES 2225/4885
US-11465992-B2 Sulfonamide carboxamide compounds NLRP3, NOD1, PYCARD TAS2R14 784/4885CXCR3 1232/4885PTGES 2084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.