Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002892 | 0.82 | NPC1 (0.52) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL25002912 | 0.77 | PLA2G2A (0.48) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL25002930 | 0.77 | RAB9A (0.49) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL25002922 | 0.75 | KMT2A (0.56) | KMT2ASMN1; SMN2MAPTNPC1KDM4E | |
| SCHEMBL25002900 | 0.74 | KMT2A (0.51) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL25002901 | 0.71 | ADORA3 (0.49) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL25002890 | 0.70 | MAP4K4 (0.51) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL22027749 | 0.70 | KMT2A (0.42) | KMT2ARAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL3140118 | 0.70 | SCN9A (0.57) | KMT2AMAPTMEN1SCN9A | |
| SCHEMBL14741986 | 0.70 | MAPT (0.48) | KMT2ASMN1; SMN2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668502-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | AbbVie Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019035927-A1 | MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE | ABBVIE INC. (US) | 2019-02-21 | — | — | WO | disclosed |