Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002912 | 0.95 | PLA2G2A (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25002930 | 0.89 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25003134 | 0.86 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25002922 | 0.85 | KMT2A (0.56) | NPC1SMN1; SMN2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL20746299 | 0.82 | KMT2A (0.41) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7338798 | 0.82 | MAPT (0.55) | NPC1SMN1; SMN2ALDH1A1KDM4EALPL | |
| SCHEMBL25003794 | 0.81 | PLK1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25002900 | 0.80 | KMT2A (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL25002901 | 0.80 | ADORA3 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL25002890 | 0.79 | MAP4K4 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |