Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23515046 | 0.81 | HRH4 (0.45) | HRH4MAPK1PROKR1KDM4E | |
| SCHEMBL23515312 | 0.80 | HRH4 (0.53) | HRH4 | |
| SCHEMBL20757090 | 0.78 | HRH4 (0.47) | HRH4MAPK1PROKR1TMEM97 | |
| SCHEMBL425041 | 0.77 | HRH4 (0.56) | HRH4MAPK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL23636750 | 0.76 | ADRB1 (0.41) | HRH4KDM4EALDH1A1 | |
| Water SCHEMBL28114608 | 0.75 | HRH4 (0.54) | HRH4MAPK1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL9455784 | 0.75 | HRH4 (0.58) | HRH4MAPK1KDM4EALDH1A1TSHR | |
| SCHEMBL26788467 | 0.75 | HRH4 (0.44) | HRH4TMEM97LDHACHRM4 | |
| SCHEMBL21186191 | 0.73 | HRH4 (0.50) | HRH4KDM4ELDHA | |
| SCHEMBL21342320 | 0.72 | PRKDC (0.52) | PROKR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019036377-A1 | TRICYCLIC COMPOUNDS AS HISTONE METHYL-TRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-02-21 | — | — | WO | disclosed |