Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 4/20 | 0.47 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.47 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.47 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.47 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.47 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.47 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.47 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.47 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.47 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.47 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.47 |
| ▸ | CACNA1E | Q15878 | 3/20 | 0.47 |
| ▸ | CACNA2D4 | Q7Z3S7 | 3/20 | 0.47 |
| ▸ | CACNA2D3 | Q8IZS8 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075203 | 0.89 | C5AR1 (0.49) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2077305 | 0.87 | SLC16A3 (0.44) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2073415 | 0.87 | ACHE (0.46) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2073996 | 0.87 | NR1H2 (0.52) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2074756 | 0.85 | KDM1A (0.44) | P2RX3CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL2074365 | 0.85 | CTSS (0.53) | P2RX3CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL2074833 | 0.83 | KCNK3 (0.46) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2073906 | 0.83 | SLC16A3 (0.48) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2076060 | 0.83 | P2RX7 (0.41) | P2RX3CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL2073869 | 0.83 | MEN1 (0.46) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905774-B1 | Fused heterocyclic compounds as serotonin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2013-02-20 | — | — | EP | disclosed |
| US-7897771-B2 | Fused heterocyclic compounds | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-01 | — | — | US | disclosed |
| US-20110040088-A1 | FUSED HETEROCYCLIC COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-17 | — | — | US | disclosed |
| US-20090270370-A1 | FUSED HETEROCYCLIC COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-29 | — | — | US | disclosed |
| US-7579470-B2 | Fused heterocyclic compounds | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-25 | — | — | US | disclosed |
| EP-1668014-B1 | FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-01-14 | — | — | EP | disclosed |
| US-7402680-B2 | Fused heterocyclic compounds | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-07-22 | — | — | US | disclosed |
| EP-1944306-A1 | Fused heterocyclic compounds as serotonin receptor modulators | Janssen Pharmaceutica, N.V. (BE) | 2008-07-16 | — | — | EP | disclosed |
| US-20080103132-A1 | FUSED HETEROCYCLIC COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-01 | — | — | US | disclosed |
| EP-1905774-A1 | Fused heterocyclic compounds as serotonin receptor modulators | Janssen Pharmaceutica, N.V. (BE) | 2008-04-02 | — | — | EP | disclosed |
| EP-1668014-A2 | FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-14 | — | — | EP | disclosed |
| US-20050119295-A1 | Fused heterocyclic compounds | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-06-02 | — | — | US | disclosed |
| WO-2005040169-A2 | FUSED HETEROCYCLIC COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119295-A1 | Fused heterocyclic compounds | TPH1, HTR3A, HTR3B | P2RX3 296/4885CACNB4 1658/4885CACNA1A 1102/4885 |
| US-20110040088-A1 | FUSED HETEROCYCLIC COMPOUNDS | TPH1, HTR3A, HTR3B | P2RX3 296/4885CACNB4 1658/4885CACNA1A 1102/4885 |
| US-20090270370-A1 | FUSED HETEROCYCLIC COMPOUNDS | TPH1, HTR3A, HTR3B | P2RX3 296/4885CACNB4 1658/4885CACNA1A 1102/4885 |
| US-20080103132-A1 | FUSED HETEROCYCLIC COMPOUNDS | TPH1, HTR3A, HTR3B | P2RX3 296/4885CACNB4 1658/4885CACNA1A 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.