Sugi Predict

Sugi Predict / Compounds / SCHEMBL2076302

SCHEMBL2076302

SCHEMBL2076302

COc1cc([N+](=O)[O-])ccc1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.54
▸ TDP1 Q9NUW8 1/20 0.53
▸ CYP19A1 P11511 1/20 0.48
▸ PTGS2 P35354 1/20 0.48
▸ NPC1 O15118 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ LMNA P02545 3/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47
▸ PKM P14618 1/20 0.46
▸ ALPL P05186 1/20 0.44
▸ KMT2A Q03164 4/20 0.44
▸ MEN1 O00255 3/20 0.43
▸ MAPT P10636 2/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ TTR P02766 2/20 0.43
▸ POLB P06746 1/20 0.43
▸ MAPK1 P28482 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ DRD2 P14416 1/20 0.43
▸ AMY1A P0DUB6 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1157615 0.94 HTT (0.54) HTTTDP1CYP19A1PTGS2NPC1
SCHEMBL9687587 0.92 HTT (0.46) HTTTDP1CYP19A1PTGS2NPC1
SCHEMBL6825987 0.84 HTT (0.59) HTTTDP1RAB9ALMNASMN1; SMN2
SCHEMBL61078 0.84 ALDH1A1 (0.51) HTTTDP1LMNASMN1; SMN2KMT2A
SCHEMBL6823722 0.84 HTT (0.59) HTTTDP1RAB9ALMNASMN1; SMN2
SCHEMBL62955 0.84 ALDH1A1 (0.50) HTTTDP1LMNASMN1; SMN2ALPL
SCHEMBL18359615 0.82 S1PR4 (0.48) HTTTDP1LMNASMN1; SMN2KMT2A
SCHEMBL16098596 0.82 TDP1 (0.60) HTTTDP1RAB9ALMNASMN1; SMN2
SCHEMBL31705367 0.82 HTT (0.45) HTTTDP1CYP19A1PTGS2LMNA
SCHEMBL223562 0.81 LMNA (0.51) HTTTDP1CYP19A1PTGS2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106260-A1 NOVEL DIPHENYLETHER DERIVATIVE AND USE THEREOF 광주과학기술원 2026-05-21 — — WO disclosed
US-7902356-B2 Thiazolopyridinone derivates as MCH receptor antagonists ELI LILLY AND COMPANY (US) 2011-03-08 — — US disclosed
US-7902356-B2 Thiazolopyridinone derivates as MCH receptor antagonists ELI LILLY AND COMPANY (US) 2011-03-08 — — US disclosed
EP-1828207-B1 THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS LILLY CO ELI (US) 2009-10-28 — — EP disclosed
US-20090233919-A1 THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY 2009-09-17 — — US disclosed
US-20090233919-A1 THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY 2009-09-17 — — US disclosed
EP-1828207-A1 THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2007-09-05 — — EP disclosed
WO-2006066174-A1 THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2006-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233919-A1 THIAZOLOPYRIDINONE DERIVATES AS MCH RECEPTOR ANTAGONISTS MCHR1, MCHR2, MC1R HTT 181/4885TDP1 2242/4885CYP19A1 682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.