Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.82 |
| ▸ | PPARD | Q03181 | 3/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | PPARA | Q07869 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.55 |
| ▸ | ICMT | O60725 | 5/20 | 0.54 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.52 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.52 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.52 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.52 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769700 | 0.94 | LMNA (0.75) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL8171661 | 0.91 | LMNA (0.75) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL6893171 | 0.90 | LMNA (1.00) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769719 | 0.90 | ALDH1A1 (0.65) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769685 | 0.85 | ALDH1A1 (0.60) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769736 | 0.85 | ALDH1A1 (0.60) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL27794788 | 0.84 | LMNA (0.84) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769653 | 0.84 | ALDH1A1 (0.61) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL27773527 | 0.83 | LMNA (0.67) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769651 | 0.82 | ALDH1A1 (0.60) | LMNAALDH1A1PPARDPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |