Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PPARD | Q03181 | 3/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.53 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.50 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | CDC25A | P30304 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | ICMT | O60725 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769700 | 0.90 | LMNA (0.75) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769743 | 0.84 | LMNA (0.82) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769719 | 0.83 | ALDH1A1 (0.65) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL6769060 | 0.81 | CREBBP (0.52) | ALDH1A1LMNA | |
| SCHEMBL20769651 | 0.81 | ALDH1A1 (0.60) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL8181539 | 0.79 | CDC25A (0.52) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769731 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20769736 | 0.79 | ALDH1A1 (0.60) | ALDH1A1LMNAPPARDPPARGPPARA | |
| SCHEMBL20789160 | 0.79 | ADRA1D (0.43) | ALDH1A1LMNAACLY | |
| SCHEMBL20787986 | 0.79 | PDE4A (0.47) | ALDH1A1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |