Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | PPARD | Q03181 | 3/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | PPARA | Q07869 | 2/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.62 |
| ▸ | ICMT | O60725 | 6/20 | 0.58 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769743 | 0.94 | LMNA (0.82) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769719 | 0.93 | ALDH1A1 (0.65) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769653 | 0.90 | ALDH1A1 (0.61) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769651 | 0.88 | ALDH1A1 (0.60) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769685 | 0.88 | ALDH1A1 (0.60) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769736 | 0.88 | ALDH1A1 (0.60) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL2004159 | 0.86 | PLA2G2A (0.81) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL20769731 | 0.86 | ALDH1A1 (0.58) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL6893171 | 0.86 | LMNA (1.00) | LMNAALDH1A1PPARDPPARGPPARA | |
| SCHEMBL7683025 | 0.85 | ICMT (0.68) | LMNAALDH1A1PLA2G2AICMTPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |