Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.48 |
| ▸ | SLC2A3 | P11169 | 4/20 | 0.48 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075111 | 0.82 | SLC2A1 (0.50) | SLC2A1SLC2A3SLC2A2ALDH1A1KDM4E | |
| SCHEMBL2079322 | 0.81 | PDE9A (0.37) | SLC2A1SLC2A3SLC2A2EGFR | |
| SCHEMBL2078784 | 0.80 | PDE9A (0.37) | SLC2A1SLC2A3SLC2A2MAPTLMNA | |
| SCHEMBL3780063 | 0.80 | SLC2A1 (0.48) | SLC2A1SLC2A3SLC2A2ALDH1A1KDM4E | |
| SCHEMBL2077090 | 0.77 | KDM4E (0.48) | SLC2A1SLC2A3SLC2A2ALDH1A1KDM4E | |
| SCHEMBL2078604 | 0.74 | KDM4E (0.46) | SLC2A1SLC2A3SLC2A2ALDH1A1KDM4E | |
| SCHEMBL2077453 | 0.74 | MAPT (0.46) | ALDH1A1KDM4EHSD17B10TSHRMEN1 | |
| SCHEMBL2075107 | 0.74 | ALDH1A1 (0.46) | SLC2A1SLC2A3ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2303695 | 0.74 | XDH (0.47) | SLC2A1SLC2A3SLC2A2ALDH1A1KDM4E | |
| SCHEMBL2078498 | 0.72 | XDH (0.47) | SLC2A1SLC2A3SLC2A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851468-B2 | Substituted pyrazolo[3,4-d]pyrimidines | CEPHALON, INC. (US) | 2010-12-14 | — | — | US | claimed |
| US-8354414-B2 | Substituted bicyclic pyrimidines | CEPHALON, INC (US) | 2013-01-15 | — | — | US | disclosed |
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | CEPHALON, INC. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | DPYD, P2RX5, P2RX7 | SLC2A1 1500/4885SLC2A3 2379/4885SLC2A2 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.