Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 7/20 | 0.81 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 1/20 | 0.57 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.55 |
| ▸ | FEN1 | P39748 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | BAX | Q07812 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28342957 | 0.98 | SRD5A2 (0.78) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL13599782 | 0.96 | SRD5A2 (0.88) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL2866068 | 0.96 | SRD5A2 (0.88) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL235530 | 0.96 | SRD5A2 (0.88) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL1082112 | 0.96 | SRD5A2 (0.88) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL9536469 | 0.96 | SRD5A2 (0.88) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL22415445 | 0.93 | SRD5A2 (0.84) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL1069817 | 0.93 | SRD5A2 (0.84) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL234249 | 0.93 | SRD5A2 (0.84) | SRD5A2PARP10POLBELANEERCC5 | |
| SCHEMBL26759067 | 0.93 | SRD5A2 (0.84) | SRD5A2PARP10POLBELANEERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358924-B2 | Dissociation of a 1,4-bis (4-phenoxybenzoyl)benzene-lewis acid complex in an aqueous solution | ARKEMA FRANCE (FR) | 2022-06-14 | — | — | US | disclosed |
| EP-3650435-B1 | DISSOCIATION OF 1,4-BIS (4-PHENOXYBENZOYL)BENZENE - LEWIS ACID COMPLEX IN A PROTIC SOLVENT | ARKEMA FRANCE (FR) | 2021-07-07 | — | — | EP | disclosed |
| US-10793500-B2 | Dissociation of 1,4-bis (4-phenoxybenzoyl)benzene—Lewis acid complex in a protic solvent | ARKEMA FRANCE (FR) | 2020-10-06 | — | — | US | disclosed |
| EP-3404011-B1 | DISSOCIATION OF A 1,4-BIS(4-PHENOXYBENZOYL)BENZENE-LEWIS ACID-COMPLEX IN AN AQUEOUS SOLUTION | ARKEMA FRANCE (FR) | 2020-08-26 | — | — | EP | disclosed |
| EP-3650435-A1 | DISSOCIATION OF 1,4-BIS (4-PHENOXYBENZOYL)BENZENE - LEWIS ACID COMPLEX IN A PROTIC SOLVENT | Arkema France (FR) | 2020-05-13 | — | — | EP | disclosed |
| US-20200109100-A1 | DISSOCIATION OF A 1,4-BIS (4-PHENOXYBENZOYL)BENZENE- LEWIS ACID COMPLEX IN AN AQUEOUS SOLUTION | ARKEMA FRANCE (FR) | 2020-04-09 | — | — | US | disclosed |
| US-20190077739-A1 | DISSOCIATION OF 1,4-BIS (4-PHENOXYBENZOYL)BENZENE - LEWIS ACID COMPLEX IN A PROTIC SOLVENT | ARKEMA FRANCE (FR) | 2019-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077739-A1 | DISSOCIATION OF 1,4-BIS (4-PHENOXYBENZOYL)BENZENE - LEWIS ACID COMPLEX IN A PROTIC SOLVENT | PBRM1, PSMB7, PSMC2 | SRD5A2 4033/4885PARP10 2390/4885POLB 1930/4885 |
| US-11358924-B2 | Dissociation of a 1,4-bis (4-phenoxybenzoyl)benzene-lewis acid complex in an aqueous solution | SSB, PBRM1, TLL2 | SRD5A2 3802/4885PARP10 4548/4885POLB 871/4885 |
| US-10793500-B2 | Dissociation of 1,4-bis (4-phenoxybenzoyl)benzene—Lewis acid complex in a protic solvent | PBRM1, PSMB7, PSMB4 | SRD5A2 4014/4885PARP10 2435/4885POLB 1898/4885 |
| US-20200109100-A1 | DISSOCIATION OF A 1,4-BIS (4-PHENOXYBENZOYL)BENZENE- LEWIS ACID COMPLEX IN AN AQUEOUS SOLUTION | PBRM1, TLL1, BAP1 | SRD5A2 3648/4885PARP10 4412/4885POLB 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.