Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31703779 | 0.84 | ALDH1A1 (0.50) | KMT2AMEN1MAPTGAAPOLB | |
| SCHEMBL436166 | 0.84 | ALDH1A1 (0.50) | KMT2AMEN1MAPTGAAPOLB | |
| SCHEMBL4221719 | 0.83 | KMT2A (0.47) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL27493913 | 0.82 | S100A4 (0.44) | KMT2AMEN1MAPTGAAPOLB | |
| SCHEMBL2081137 | 0.81 | KMT2A (0.57) | KMT2AMEN1MAPTCES2CES1 | |
| SCHEMBL29155628 | 0.81 | NR1H3 (0.45) | KMT2AMEN1MAPTGAAPOLB | |
| SCHEMBL2098096 | 0.78 | MAPT (0.40) | KMT2AMEN1MAPTGAAPOLB | |
| SCHEMBL12983729 | 0.77 | KMT2A (0.44) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL17500927 | 0.77 | GAA (0.40) | KMT2AMEN1MAPTGAAPOLB | |
| SCHEMBL14321408 | 0.77 | ALDH1A1 (0.49) | KMT2AMEN1MAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2497771-A1 | 4 -substituted azaadamantane derivatives and methods of use thereof | Abbott Laboratories (US) | 2012-09-12 | — | — | EP | disclosed |
| EP-2139891-B1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LAB (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20120196890-A1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | BUNNELLE WILLIAM H (US) | 2012-08-02 | — | — | US | disclosed |
| EP-2455383-A2 | 4 -substituted azaadamantane derivatives and methods of use thereof | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| US-8163915-B2 | Modulate neuronal nicotinic receptor activity; attention deficit disorder, Parkinson's, Tourette's, schizophrenia, cognitive deficits, dementia; acute pain, post-surgical pain, chronic pain, inflammatory pain; 1-azatricyclo[3.3.1.13,7]decan-4-one O-2-naphthyloxime | ABBOTT LABORATORIES (US) | 2012-04-24 | — | — | US | disclosed |
| US-7906538-B2 | Parasiticides; nematocides; crop protection | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2011-03-15 | — | — | US | disclosed |
| EP-2139891-A1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20080262048-A1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF NOVEL TRIFLUOROMETHANESULFONANILIDE OXIME ETHER DERIVATIVES | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 2008-10-23 | — | — | US | disclosed |
| US-20080255180-A1 | 4-Substituted Azaadamantane Derivatives and Methods of Use Thereof | ABBOTT LABORATORIES (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008118745-A1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2008-10-02 | — | — | WO | disclosed |
| EP-1799636-B1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF NOVEL TRIFLUOROMETHANESULFONANILIDE OXIME ETHER DERIVATIVES | SCHERING PLOUGH LTD (CH) | 2008-08-27 | — | — | EP | disclosed |
| US-7312248-B2 | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (US) | 2007-12-25 | — | — | US | disclosed |
| US-20060063841-A1 | Parasiticides; nematocides; crop protection | SCHERING-PLOUGH LTD. (CH) | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255180-A1 | 4-Substituted Azaadamantane Derivatives and Methods of Use Thereof | UGT1A4, CYP4B1, CYP4A11 | KMT2A 650/4885MEN1 581/4885MAPT 3972/4885 |
| US-20120196890-A1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | UGT1A4, CYP4B1, CYP4A11 | KMT2A 650/4885MEN1 581/4885MAPT 3972/4885 |
| US-20060063841-A1 | Parasiticides; nematocides; crop protection | TRHDE, DDT, EPHX1 | KMT2A 1304/4885MEN1 2617/4885MAPT 4715/4885 |
| US-20080262048-A1 | CONTROL OF PARASITES IN ANIMALS BY THE USE OF NOVEL TRIFLUOROMETHANESULFONANILIDE OXIME ETHER DERIVATIVES | TRHDE, EPX, EPHX1 | KMT2A 896/4885MEN1 3201/4885MAPT 4867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.