Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079703 | 0.78 | KMT2A (0.57) | MAPTKMT2AMEN1RECQLGAA | |
| SCHEMBL15647281 | 0.76 | KMT2A (0.39) | MAPTKMT2AMEN1RECQLIDO1 | |
| SCHEMBL6922748 | 0.74 | KMT2A (0.66) | MAPTKMT2AMEN1RECQLGAA | |
| SCHEMBL436166 | 0.73 | ALDH1A1 (0.50) | MAPTKMT2AMEN1RECQLGAA | |
| SCHEMBL31703779 | 0.73 | ALDH1A1 (0.50) | MAPTKMT2AMEN1RECQLGAA | |
| SCHEMBL4221719 | 0.73 | KMT2A (0.47) | MAPTKMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL29155628 | 0.70 | NR1H3 (0.45) | MAPTKMT2AMEN1RECQLGAA | |
| SCHEMBL2081137 | 0.70 | KMT2A (0.57) | MAPTKMT2AMEN1RECQLGAA | |
| SCHEMBL14161375 | 0.70 | CHRNA3 (0.41) | CHRNB2CHRNA4 | |
| SCHEMBL23994462 | 0.69 | CHRNB2 (0.38) | KMT2AMEN1CHRNB2CHRNA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139891-B1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | ABBOTT LAB (US) | 2012-09-05 | — | — | EP | disclosed |
| US-20120196890-A1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | BUNNELLE WILLIAM H (US) | 2012-08-02 | — | — | US | disclosed |
| EP-2455383-A2 | 4 -substituted azaadamantane derivatives and methods of use thereof | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| US-8163915-B2 | Modulate neuronal nicotinic receptor activity; attention deficit disorder, Parkinson's, Tourette's, schizophrenia, cognitive deficits, dementia; acute pain, post-surgical pain, chronic pain, inflammatory pain; 1-azatricyclo[3.3.1.13,7]decan-4-one O-2-naphthyloxime | ABBOTT LABORATORIES (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080255180-A1 | 4-Substituted Azaadamantane Derivatives and Methods of Use Thereof | ABBOTT LABORATORIES (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255180-A1 | 4-Substituted Azaadamantane Derivatives and Methods of Use Thereof | UGT1A4, CYP4B1, CYP4A11 | MAPT 3972/4885KMT2A 650/4885MEN1 581/4885 |
| US-20120196890-A1 | 4-SUBSTITUTED AZAADAMANTANE DERIVATIVES AND METHODS OF USE THEREOF | UGT1A4, CYP4B1, CYP4A11 | MAPT 3972/4885KMT2A 650/4885MEN1 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.