Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17696428 | 0.77 | ALOX15 (0.33) | ALDH1A1HTTALOX15SMN1; SMN2MEN1 | |
| SCHEMBL21546435 | 0.75 | GBA1 (0.46) | ALDH1A1HTTALOX15SMN1; SMN2KDM4E | |
| SCHEMBL23570033 | 0.75 | PGK1 (0.35) | L3MBTL1ALOX15SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL336656 | 0.73 | PTGER4 (0.36) | ALDH1A1ALDH1A3ALDH3A1L3MBTL1PTGER4 | |
| SCHEMBL17693920 | 0.72 | CRHR1 (0.34) | ALDH1A1HTTALOX15SMN1; SMN2TERT | |
| SCHEMBL335669 | 0.72 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1PTGER4POLBCASP6 | |
| SCHEMBL29955433 | 0.72 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1PTGER4POLBCASP6 | |
| SCHEMBL30013048 | 0.71 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1PTGER4POLBCASP6 | |
| SCHEMBL29954177 | 0.71 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1PTGER4POLBCASP6 | |
| SCHEMBL22666896 | 0.70 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1PTGER4POLBCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |
| WO-2019049061-A1 | 5-(1 H-BENZO[D]IMIDAZO-2-YL)-PYRIDIN-2-AMINE AND 5-(3H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-PYRIDIN-2-AMINE DERIVATIVES AS C-MYC AND P300/CBP HISTONE ACETYLTRANSFERASE INHIBITORS FOR TREATING CANCER | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-03-14 | — | — | WO | disclosed |