Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 4/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20798251 | 0.92 | FFAR4 (0.36) | ALDH1A1LMNAHTTABL1IL1B | |
| SCHEMBL20798320 | 0.90 | ALDH1A1 (0.35) | ALDH1A1IL1BP2RX7EPHX2TSHR | |
| SCHEMBL23406989 | 0.88 | GPR6 (0.42) | PTGDR2 | |
| SCHEMBL20798256 | 0.87 | ALDH1A1 (0.46) | ALDH1A1EPHX2TSHRMAPK1PTGDR2 | |
| SCHEMBL23407034 | 0.87 | FFAR4 (0.41) | ALDH1A1LMNAIL1BP2RX7PTGDR2 | |
| SCHEMBL23434986 | 0.87 | ALDH1A1 (0.33) | ALDH1A1LMNAIL1BP2RX7EPHX2 | |
| SCHEMBL20798254 | 0.86 | MEN1 (0.40) | ALDH1A1LMNATSHRMAPK1PTGDR2 | |
| SCHEMBL23407048 | 0.85 | POLB (0.38) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20798226 | 0.84 | CCR2 (0.39) | ALDH1A1EPHX2TSHRMAPK1MAPT | |
| SCHEMBL20798213 | 0.84 | DRD2 (0.37) | IL1BP2RX7EPHX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629139-B2 | Small molecule inhibitors of Ebola and Lassa fever viruses and methods of use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-18 | — | — | US | disclosed |
| US-20210163454-A1 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2021-06-03 | — | — | US | disclosed |
| US-20210163454-A1 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2021-06-03 | — | — | US | disclosed |
| WO-2019051396-A1 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629139-B2 | Small molecule inhibitors of Ebola and Lassa fever viruses and methods of use | CCR8, RPS8, HDHD5 | ALDH1A1 3354/4885LMNA 1798/4885HTT 3394/4885 |
| US-20210163454-A1 | SMALL MOLECULE INHIBITORS OF EBOLA AND LASSA FEVER VIRUSES AND METHODS OF USE | CCR8, RPS8, HDHD5 | ALDH1A1 3354/4885LMNA 1798/4885HTT 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.