Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376730 | 1.00 | RIPK1 (0.47) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL2079846 | 1.00 | RIPK1 (0.47) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL10526965 | 0.83 | RIPK1 (0.49) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL17864360 | 0.82 | PRKACA (0.49) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL10211441 | 0.81 | RIPK1 (0.47) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL10211434 | 0.81 | RIPK1 (0.47) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL11744344 | 0.79 | SLC6A2 (0.50) | TRPA1KDM4EL3MBTL1CYP2D6SLC6A2 | |
| SCHEMBL1520851 | 0.79 | LMNA (0.52) | RIPK1EPHX2KDM4E | |
| SCHEMBL18539292 | 0.79 | AOC3 (0.52) | RIPK1ROCK2ROCK1MAPK13RPS6KA5 | |
| SCHEMBL16323165 | 0.79 | LMNA (0.52) | RIPK1EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035789-B | (1S,5S) -3- (5, 6-dichloro-3-pyridinyl) -3, 6-diazabicyclo [3.2.0] heptane | ABBOTT LAB | 2011-08-17 | — | — | CN | disclosed |
| US-7902371-B2 | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate | ABBOTT LABORATORIES (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902371-B2 | (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate | ABBOTT LABORATORIES (US) | 2011-03-08 | — | — | US | disclosed |
| EP-1771451-B1 | (1S,5S)-3-(5,6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | ABBOTT LAB (US) | 2010-09-08 | — | — | EP | disclosed |
| EP-1771451-B1 | (1S,5S)-3-(5,6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | ABBOTT LAB (US) | 2010-09-08 | — | — | EP | disclosed |
| US-20090203664-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6- DIAZABICYCLO[3.2.0]HEPTANE | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090203664-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6- DIAZABICYCLO[3.2.0]HEPTANE | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090198067-A1 | (1S,5S)-3-(5,6-Dichloropyridin-3-YL)-3,6-Diazabicyclo[3.2.0]Heptane Benzenesulfonate | ABBOTT LABORATORIES (US) | 2009-08-06 | — | — | US | disclosed |
| US-20090198067-A1 | (1S,5S)-3-(5,6-Dichloropyridin-3-YL)-3,6-Diazabicyclo[3.2.0]Heptane Benzenesulfonate | ABBOTT LABORATORIES (US) | 2009-08-06 | — | — | US | disclosed |
| US-7538226-B2 | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane | ABBOTT LABORATORIES (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080070891-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE | ABBVIE INC. | 2008-03-20 | — | — | US | disclosed |
| US-20080004448-A1 | (1S,5S)-3-(5.6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | ABBVIE INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004448-A1 | (1S,5S)-3-(5.6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | ABBVIE INC. | 2008-01-03 | — | — | US | disclosed |
| CN-101035789-A | (1S,5S) -3- (5, 6-dichloro-3-pyridinyl) -3, 6-diazabicyclo [3.2.0] heptane | ABBOTT LAB (US) | 2007-09-12 | — | — | CN | disclosed |
| EP-1778692-A2 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE | ABBOTT LABORATORIES (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1771451-A2 | (1S,5S)-3-(5,6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | ABBOTT LABORATORIES (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006019668-A2 | (1S,5S)-3-(5,6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | ABBOTT LABORATORIES (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006019660-A2 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE | ABBOTT LABORATORIES (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20060035936-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE | ABBVIE INC. | 2006-02-16 | — | — | US | disclosed |
| US-20060035937-A1 | (1S,5S)-3-(5,6-dichloropyridin-3-YL)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate | ABBVIE INC. | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035937-A1 | (1S,5S)-3-(5,6-dichloropyridin-3-YL)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate | DHPS, HCN2, DCPS | RIPK1 4413/4885ROCK2 4417/4885ROCK1 4416/4885 |
| US-20080004448-A1 | (1S,5S)-3-(5.6-DICHLOROPYRIDIN-3-YL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE BENZENESULFONATE | DHPS, HCN2, DCPS | RIPK1 4411/4885ROCK2 4428/4885ROCK1 4427/4885 |
| US-20080070891-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE | CHRNA6, CHRNA5, CHRNA3 | RIPK1 4034/4885ROCK2 3474/4885ROCK1 3243/4885 |
| US-20090203664-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6- DIAZABICYCLO[3.2.0]HEPTANE | CHRNA6, CHRNA5, CHRNA3 | RIPK1 4034/4885ROCK2 3474/4885ROCK1 3243/4885 |
| US-20090198067-A1 | (1S,5S)-3-(5,6-Dichloropyridin-3-YL)-3,6-Diazabicyclo[3.2.0]Heptane Benzenesulfonate | DHPS, HCN2, DCPS | RIPK1 4413/4885ROCK2 4417/4885ROCK1 4416/4885 |
| US-20060035936-A1 | (1S,5S)-3-(5,6-DICHLORO-3-PYRIDINYL)-3,6-DIAZABICYCLO[3.2.0]HEPTANE | CHRNA6, CHRNA5, CHRNA3 | RIPK1 4034/4885ROCK2 3474/4885ROCK1 3243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.