Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.57 |
| ▸ | KMO | O15229 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17954296 | 0.85 | GPR35 (0.57) | GPR35KMOMKNK1MKNK2GPR17 | |
| SCHEMBL17954301 | 0.73 | NR4A2 (0.56) | GPR35MKNK1MKNK2CYP1A2GSK3B | |
| SCHEMBL14703002 | 0.73 | GPR35 (1.00) | GPR35KMOMKNK1MKNK2 | |
| SCHEMBL6755438 | 0.72 | MMP2 (0.55) | KMOMKNK1MKNK2PIM1PIM2 | |
| SCHEMBL29966067 | 0.72 | CYP11B1 (0.56) | CYP1A2PIM1FGFR1CHEK1QPCT | |
| SCHEMBL31441275 | 0.71 | PRMT5 (0.52) | CYP1A2GSK3BPIM1FGFR1CHEK1 | |
| SCHEMBL16610292 | 0.71 | MAPT (0.63) | CYP1A2PIM1FGFR1CHEK1CLK2 | |
| SCHEMBL206541 | 0.70 | KMO (1.00) | KMOMKNK1MKNK2CYP1A2PIM1 | |
| SCHEMBL29569537 | 0.70 | KMO (1.00) | KMOMKNK1MKNK2CYP1A2PIM1 | |
| SCHEMBL28297133 | 0.70 | KMO (1.00) | KMOMKNK1MKNK2CYP1A2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227588-B2 | 3′end caps for RNAi agents for use in RNA interference | NOVARTIS AG (CH) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227588-B2 | 3′end caps for RNAi agents for use in RNA interference | RNGTT, NSUN2, NSUN3 | GPR35 4682/4885KMO 4832/4885MKNK1 1734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.