Sugi Predict

Sugi Predict / Compounds / SCHEMBL208017

SCHEMBL208017

SCHEMBL208017

CCCCCCCCN(C)c1ccc(Nc2nc(-c3ccc(O)c(C(N)=O)c3)cs2)cc1C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 2/20 0.48
▸ GAA P10253 1/20 0.48
▸ CFTR P13569 2/20 0.47
▸ PRMT5 O14744 2/20 0.46
▸ WDR77 Q9BQA1 2/20 0.46
▸ MEN1 O00255 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ HSPD1 P10809 1/20 0.43
▸ HSPE1 P61604 1/20 0.43
▸ HPGDS O60760 1/20 0.42
▸ ENPP2 Q13822 3/20 0.41
▸ CSNK2A2 P19784 2/20 0.40
▸ CSNK2B P67870 2/20 0.40
▸ CSNK2A1 P68400 1/20 0.40
▸ CSNK2A3 Q8NEV1 1/20 0.40
▸ SIRT5 Q9NXA8 1/20 0.40
▸ PI4KB Q9UBF8 1/20 0.40
▸ PTGES O14684 1/20 0.40
▸ ALOX5 P09917 1/20 0.40
▸ EPHA2 P29317 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL206273 0.91 HSPD1 (0.50) MAPTGAACFTRPRMT5WDR77
SCHEMBL207360 0.85 PRMT5 (0.49) MAPTGAACFTRPRMT5WDR77
SCHEMBL2698387 0.84 ALOX5 (0.47) MAPTCFTRMEN1KMT2APTGES
SCHEMBL206218 0.84 PRMT5 (0.50) MAPTGAACFTRPRMT5WDR77
SCHEMBL2695728 0.83 ALOX5 (0.53) MAPTMEN1KMT2APTGESALOX5
SCHEMBL206861 0.83 ALOX5 (0.39) MAPTGAACFTRPRMT5WDR77
SCHEMBL9099540 0.82 ENPP2 (0.49) MAPTGAACFTRMEN1KMT2A
SCHEMBL206050 0.82 ALOX5 (0.38) MAPTGAACFTRPRMT5WDR77
SCHEMBL2695446 0.82 RAB9A (0.41) MAPTGAAPRMT5WDR77MEN1
SCHEMBL2699866 0.81 MEN1 (0.53) MAPTGAAMEN1KMT2AVCP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120108576-A1 THIAZOLE COMPOUNDS AND METHODS OF USE ACHILLION PHARMACEUTICALS, INC. (US) 2012-05-03 — — US disclosed
US-20120108576-A1 THIAZOLE COMPOUNDS AND METHODS OF USE ACHILLION PHARMACEUTICALS, INC. (US) 2012-05-03 — — US disclosed
US-20120108576-A1 THIAZOLE COMPOUNDS AND METHODS OF USE ACHILLION PHARMACEUTICALS, INC. (US) 2012-05-03 — — US disclosed
US-8088806-B2 Thiazole compounds and methods of use ACHILLION PHARMACEUTICALS, INC. (US) 2012-01-03 — — US disclosed
US-8088806-B2 Thiazole compounds and methods of use ACHILLION PHARMACEUTICALS, INC. (US) 2012-01-03 — — US disclosed
US-8088806-B2 Thiazole compounds and methods of use ACHILLION PHARMACEUTICALS, INC. (US) 2012-01-03 — — US disclosed
US-20070004711-A1 Thiazole compounds and methods of use ACHILLION PHARMACEUTICALS, INC. 2007-01-04 — — US disclosed
US-20070004711-A1 Thiazole compounds and methods of use ACHILLION PHARMACEUTICALS, INC. 2007-01-04 — — US disclosed
US-20070004711-A1 Thiazole compounds and methods of use ACHILLION PHARMACEUTICALS, INC. 2007-01-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120108576-A1 THIAZOLE COMPOUNDS AND METHODS OF USE PIGS, CPT1A, SLC10A1 MAPT 2207/4885GAA 1359/4885CFTR 111/4885
US-20070004711-A1 Thiazole compounds and methods of use PIGS, CPT1A, SLC10A1 MAPT 2207/4885GAA 1359/4885CFTR 111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.