Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 7/20 | 0.73 |
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.64 |
| ▸ | ESR1 | P03372 | 4/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877992 | 0.88 | CYP26A1 (0.76) | CYP26A1CYP24A1CYP19A1ITGB3ITGA2B | |
| SCHEMBL20809677 | 0.87 | CYP26A1 (0.82) | CYP26A1CYP24A1CYP19A1ESR1ESR2 | |
| SCHEMBL5095627 | 0.82 | ESR1 (0.69) | CYP26A1CYP24A1CYP19A1ESR1ESR2 | |
| SCHEMBL8158688 | 0.81 | CYP26A1 (0.86) | CYP26A1CYP24A1CYP19A1ESR1ESR2 | |
| SCHEMBL20809676 | 0.81 | CYP26A1 (0.62) | CYP26A1CYP24A1CYP19A1ESR1ESR2 | |
| SCHEMBL22105497 | 0.81 | CYP26A1 (0.56) | CYP26A1CYP24A1CYP19A1ITGB3ITGA2B | |
| SCHEMBL24362751 | 0.80 | CYP26A1 (0.49) | CYP26A1CYP24A1CYP19A1ALDH1A1CYP27A1 | |
| SCHEMBL9855381 | 0.78 | CYP26A1 (0.60) | CYP26A1CYP24A1CYP19A1ITGB3ITGA2B | |
| SCHEMBL8203668 | 0.78 | CYP26A1 (0.79) | CYP26A1CYP24A1CYP19A1ITGB3ITGA2B | |
| SCHEMBL22516995 | 0.78 | ITGB3 (0.55) | CYP26A1CYP24A1CYP19A1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091421-B2 | Benzene fused heterocyclic derivative and pharmaceutical composition comprising the same | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2021-08-17 | — | — | US | disclosed |
| US-20200190010-A1 | BENZENE FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2020-06-18 | — | — | US | disclosed |
| WO-2019051222-A1 | BENZENE FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | TAIWANJ PHARMACEUTICALS CO., LTD. (TW) | 2019-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11091421-B2 | Benzene fused heterocyclic derivative and pharmaceutical composition comprising the same | RORB, RORC, NR3C1 | CYP26A1 418/4885CYP24A1 262/4885CYP19A1 224/4885 |
| US-20200190010-A1 | BENZENE FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | RORB, RORC, NR3C1 | CYP26A1 418/4885CYP24A1 262/4885CYP19A1 224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.