Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA6 | P23280 | 2/20 | 0.45 |
| ▸ | CA5A | P35218 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20816036 | 0.83 | MET (0.43) | LMNACA12CA4CA6CA5A | |
| SCHEMBL20816037 | 0.78 | PTGS2 (0.42) | CA12CA9MAPTALDH1A1MEN1 | |
| SCHEMBL20816040 | 0.76 | OPRM1 (0.48) | LMNATP53MAPTALDH1A1MEN1 | |
| SCHEMBL28993108 | 0.74 | LMNA (0.79) | LMNACA12CA4CA6CA5A | |
| SCHEMBL28993111 | 0.74 | LMNA (0.79) | LMNACA12CA4CA6CA5A | |
| SCHEMBL22300409 | 0.73 | MEN1 (0.50) | LMNAPOLBTP53MAPTMEN1 | |
| SCHEMBL12393137 | 0.72 | HDAC1 (0.43) | LMNACA9POLBMAPTALDH1A1 | |
| SCHEMBL28388377 | 0.69 | LMNA (0.79) | LMNACA12CA4CA6CA5A | |
| SCHEMBL12393140 | 0.68 | KDM4E (0.46) | LMNACA9POLBMAPTALDH1A1 | |
| SCHEMBL25015538 | 0.68 | OPRM1 (0.57) | LMNAPOLBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577371-B2 | Small molecule histone methyltransferase SUV39H1 inhibitor and uses thereof | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2020-03-03 | — | — | US | disclosed |
| US-20190084987-A1 | Small Molecule Histone Methyltransferase SUV39H1 Inhibitor and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577371-B2 | Small molecule histone methyltransferase SUV39H1 inhibitor and uses thereof | SUV39H2, SUV39H1, EZH1 | LMNA 3237/4885CA12 3595/4885CA4 4038/4885 |
| US-20190084987-A1 | Small Molecule Histone Methyltransferase SUV39H1 Inhibitor and Uses Thereof | SUV39H2, SUV39H1, EZH1 | LMNA 3237/4885CA12 3595/4885CA4 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.