Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 8/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11491773 | 0.80 | MAPK8 (0.46) | RAD51KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL17039578 | 0.76 | TUBB4A (0.38) | PTPN1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL6341548 | 0.75 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL13003639 | 0.75 | RAD51 (0.41) | RAD51PTPN1PTPN2KDM4EALDH1A1 | |
| SCHEMBL20836377 | 0.75 | RAD51 (0.78) | RAD51PTPN1PTPN2KDM4EALDH1A1 | |
| SCHEMBL28694505 | 0.73 | MAPT (0.68) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL24104967 | 0.72 | GSR (0.40) | KDM4EALDH1A1HPGDMAPTFLT3 | |
| SCHEMBL18396423 | 0.72 | ACHE (0.38) | PTPN1PTPN2ALDH1A1MAPTFLT3 | |
| SCHEMBL20816323 | 0.71 | RAD51 (1.00) | RAD51PTPN1PTPN2KDM4EALDH1A1 | |
| SCHEMBL730440 | 0.71 | KMT2A (0.46) | KDM4EALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10973819-B2 | Small molecules inhibitors of RAD51 | THE UNIVERSITY OF CHICAGO (US) | 2021-04-13 | — | — | US | disclosed |
| US-10973819-B2 | Small molecules inhibitors of RAD51 | THE UNIVERSITY OF CHICAGO (US) | 2021-04-13 | — | — | US | disclosed |
| US-20190083491-A1 | SMALL MOLECULES INHIBITORS OF RAD51 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
| US-20190083491-A1 | SMALL MOLECULES INHIBITORS OF RAD51 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190083491-A1 | SMALL MOLECULES INHIBITORS OF RAD51 | RAD51, MRE11, DDB1 | RAD51 1/4885PTPN1 3645/4885PTPN2 3602/4885 |
| US-10973819-B2 | Small molecules inhibitors of RAD51 | RAD51, MRE11, DDB1 | RAD51 1/4885PTPN1 3645/4885PTPN2 3602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.