Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127520 | 0.83 | KCNH2 (0.59) | SMN1; SMN2SIGMAR1KCNH2TMEM97BCHE | |
| SCHEMBL21799832 | 0.83 | SIGMAR1 (0.43) | SIGMAR1KCNH2TMEM97BCHEALDH1A1 | |
| SCHEMBL172531 | 0.82 | SIGMAR1 (0.66) | SMN1; SMN2SIGMAR1BCHEGAAATM | |
| Hydrochloric Acid SCHEMBL27619587 | 0.81 | SIGMAR1 (0.63) | SMN1; SMN2SIGMAR1BCHEKMT2AMEN1 | |
| SCHEMBL172666 | 0.80 | MEN1 (0.61) | SMN1; SMN2BCHEALDH1A1KMT2AMEN1 | |
| SCHEMBL25588047 | 0.80 | MEN1 (0.61) | SMN1; SMN2BCHEALDH1A1KMT2AMEN1 | |
| SCHEMBL25588023 | 0.80 | ALDH1A1 (0.44) | SIGMAR1KCNH2TMEM97BCHEALDH1A1 | |
| SCHEMBL11816814 | 0.79 | BCHE (0.67) | SMN1; SMN2SIGMAR1KCNH2TMEM97BCHE | |
| SCHEMBL19865692 | 0.79 | LOXL2 (0.55) | SIGMAR1KCNH2TMEM97BCHEALDH1A1 | |
| SCHEMBL11235861 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2CA12CA2CA9SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427451-B1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |