Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.48 |
| ▸ | CHRNG | P07510 | 4/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.48 |
| ▸ | CHRND | Q07001 | 4/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.48 |
| ▸ | PTPRA | P18433 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20827945 | 0.91 | CTSL (0.60) | PTPN1ALDH1A1KMT2ACTSLCTSB | |
| SCHEMBL20828044 | 0.91 | PTPN1 (0.61) | PTPN1CTSLCTSBCTSSCHRNA1 | |
| SCHEMBL20816766 | 0.89 | PTPN1 (0.62) | PTPN1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL20816767 | 0.89 | PTPN1 (0.62) | PTPN1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL20828015 | 0.89 | CTSL (0.55) | PTPN1ALDH1A1KMT2ACTSLCTSB | |
| SCHEMBL20827951 | 0.87 | CTSS (0.53) | PTPN1ALDH1A1KMT2ACTSLCTSB | |
| SCHEMBL20827964 | 0.85 | OPRD1 (0.52) | PTPN1CTSLCTSBCTSSOPRD1 | |
| SCHEMBL20816552 | 0.84 | PTPN1 (0.47) | PTPN1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL20827940 | 0.83 | PTPN1 (0.52) | PTPN1KMT2AMEN1CTSLCTSB | |
| SCHEMBL20827925 | 0.83 | POLB (0.52) | PTPN1KMT2AMEN1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | Phelix Therapeutics (US) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | CTSS, CTSB, CTSL | PTPN1 4631/4885ALDH1A1 1474/4885KMT2A 1698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.