Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.55 |
| ▸ | CTSS | P25774 | 2/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.49 |
| ▸ | CHRNG | P07510 | 2/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.49 |
| ▸ | CHRND | Q07001 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 3/20 | 0.48 |
| ▸ | ACE | P12821 | 3/20 | 0.48 |
| ▸ | CPA1 | P15085 | 3/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20827945 | 0.95 | CTSL (0.60) | CTSLCTSSCTSBALDH1A1PTPN1 | |
| SCHEMBL20827951 | 0.91 | CTSS (0.53) | CTSLCTSSCTSBALDH1A1PTPN1 | |
| SCHEMBL20827937 | 0.89 | PTPN1 (0.57) | CTSLCTSSCTSBALDH1A1MAPT | |
| SCHEMBL20827964 | 0.89 | OPRD1 (0.52) | CTSLCTSSCTSBPTPN1MME | |
| SCHEMBL20816662 | 0.88 | PTPN1 (0.58) | CTSLCTSSCTSBALDH1A1HPGD | |
| SCHEMBL20816899 | 0.88 | PTPN1 (0.58) | CTSLCTSSCTSBALDH1A1HPGD | |
| SCHEMBL20816879 | 0.88 | PTPN1 (0.58) | CTSLCTSSCTSBALDH1A1HPGD | |
| SCHEMBL20828044 | 0.88 | PTPN1 (0.61) | CTSLCTSSCTSBPTPN1CHRNA1 | |
| SCHEMBL20816664 | 0.88 | PTPN1 (0.58) | CTSLCTSSCTSBALDH1A1HPGD | |
| SCHEMBL20827925 | 0.86 | POLB (0.52) | CTSLCTSSCTSBPTPN1CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | Phelix Therapeutics (US) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190085024-A1 | Alpha-Ketoamide Inhibitors Of Cysteine Proteases | CTSS, CTSB, CTSL | CTSL 3/4885CTSS 1/4885CTSB 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.