Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 1/20 | 0.70 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.66 |
| ▸ | ITGAV | P06756 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | DUSP26 | Q9BV47 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12717765 | 0.84 | PTP4A3 (0.83) | PTP4A3ITGB3ITGAVKDM4EMEN1 | |
| SCHEMBL30117305 | 0.82 | PTP4A3 (1.00) | PTP4A3ITGB3ITGAVKDM4EMEN1 | |
| SCHEMBL12717644 | 0.79 | ITGB3 (1.00) | PTP4A3ITGB3ITGAVKDM4EMEN1 | |
| SCHEMBL12177369 | 0.79 | LMNA (0.62) | KDM4EMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL12177489 | 0.76 | ALDH1A1 (0.57) | PTP4A3ITGB3ITGAVKDM4EMEN1 | |
| SCHEMBL14883359 | 0.74 | ITGB3 (1.00) | PTP4A3ITGB3ITGAVMEN1ALDH1A1 | |
| SCHEMBL12177391 | 0.74 | PTPN2 (0.57) | PTP4A3ITGB3ITGAVKDM4EMEN1 | |
| SCHEMBL14876908 | 0.74 | ITGB3 (1.00) | PTP4A3ITGB3ITGAVMEN1ALDH1A1 | |
| SCHEMBL14876910 | 0.74 | ITGB3 (1.00) | PTP4A3ITGB3ITGAVMEN1ALDH1A1 | |
| SCHEMBL12717615 | 0.74 | ITGB3 (1.00) | PTP4A3ITGB3ITGAVMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190092723-A1 | CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190092723-A1 | CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS | ORAI1, SARAF, CACNA1C | PTP4A3 2267/4885ITGB3 3445/4885ITGAV 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.