Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20847876 | 0.93 | HDAC4 (0.47) | HDAC4ALDH1A1ADRA1AADRA1DADRA1B | |
| SCHEMBL4555845 | 0.81 | ADRA1A (0.41) | HDAC4ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL31459475 | 0.81 | ADRA1A (0.41) | HDAC4ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL16727037 | 0.79 | BRAF (0.38) | HDAC4ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL18190501 | 0.79 | OPRM1 (0.33) | ADRA1AADRA1DADRA1BOPRM1KDM1A | |
| SCHEMBL4597770 | 0.78 | KMT2A (0.38) | ALDH1A1ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL11178032 | 0.78 | OXTR (0.50) | ALDH1A1ADRA1AADRA1DADRA1B | |
| SCHEMBL4648771 | 0.77 | OPRM1 (0.38) | ALDH1A1OPRM1SLC6A4SLC6A3 | |
| SCHEMBL31459234 | 0.76 | HDAC4 (0.43) | HDAC4OPRM1SLC6A4SLC6A3 | |
| SCHEMBL18742698 | 0.75 | BDKRB1 (0.39) | HDAC4ALDH1A1OPRM1KDM1ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288936-B1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-05-06 | — | — | EP | disclosed |
| US-10611730-B2 | Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-07 | — | — | US | disclosed |
| US-20190092735-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10611730-B2 | Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators | GRIN1, GABRE, GRIN3A | HDAC4 683/4885ALDH1A1 986/4885ADRA1A 312/4885 |
| US-20190092735-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | GRIN1, GABRE, GRIN3A | HDAC4 683/4885ALDH1A1 986/4885ADRA1A 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.