Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31459475 | 1.00 | ADRA1A (0.41) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL8747130 | 0.92 | HDAC4 (0.45) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL18742441 | 0.92 | HDAC4 (0.41) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL7963694 | 0.87 | ADRA1A (0.38) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL28689514 | 0.87 | SCD (0.40) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL10297980 | 0.86 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BSCDOPRM1 | |
| Hydrochloric Acid SCHEMBL30389297 | 0.86 | ADRA1A (0.37) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| Hydrochloric Acid SCHEMBL3177020 | 0.86 | ADRA1A (0.37) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL2288498 | 0.86 | ADRA1A (0.42) | ADRA1AADRA1DADRA1BSCDHDAC4 | |
| SCHEMBL6884854 | 0.84 | OPRM1 (0.56) | ADRA1AADRA1DADRA1BSCDOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | claimed |
| CN-113861072-A | Preparation method of aryl cyclopropane compound | 上海麦克林生化科技有限公司 | 2021-12-31 | — | — | CN | disclosed |
| EP-2134692-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | Wyeth a Corporation of the State of Delaware (US) | 2009-12-23 | — | — | EP | disclosed |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
| WO-2008121817-A2 | QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION | WYETH (US) | 2008-10-09 | — | — | WO | disclosed |
| CN-1915231-A | Use of nonsteroidal in preparing drug of antiinflammatory agents | SCHERING AG (DE) | 2007-02-21 | — | — | CN | disclosed |
| US-7166592-B2 | Antiinflammatory agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7129270-B2 | Nonsteroidal antiinflammatory agents | Schėring AG (DE) | 2006-10-31 | — | — | US | disclosed |
| EP-1046635-B1 | Process for preparing an aromatic compound substituted by a tertiary nitrile | PFIZER PROD INC (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20040254249-A1 | Nonsteroidal antiinflammatory agents | JAROCH STEFAN (DE) | 2004-12-16 | — | — | US | disclosed |
| CN-1444570-A | Non-steroidal anti-inflammatory drugs | SCHERING AG (DE) | 2003-09-24 | — | — | CN | disclosed |
| EP-1309571-A1 | NON-STEROIDAL INFLAMMATION INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-05-14 | — | — | EP | disclosed |
| US-20020077356-A1 | Nonsteroidal antiinflammatory agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-06-20 | — | — | US | disclosed |
| WO-2002010143-A1 | NON-STEROIDAL INFLAMMATION INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-02-07 | — | — | WO | disclosed |
| US-6303782-B1 | TREATING A FLUORINE-SUBSTITUTED AROMATIC COMPOUND WITH A SECONDARY NITRILE IN THE PRESENCE OF A BASE | PFIZER INC | 2001-10-16 | — | — | US | disclosed |
| EP-1046635-A1 | Process for preparing an aromatic compound substituted by a tertiary nitrile | Pfizer Products Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| EP-0310954-B1 | ORTHO-SUBSTITUTED CARBOXYLIC ACID BENZYL ESTERS AND FUNGICIDES CONTAINING THESE COMPOUNDS | BASF Aktiengesellschaft (DE) | 1990-11-22 | — | — | EP | disclosed |
| US-4952720-A | Ortho-substituted benzyl carboxylates and fungicides which contain these compounds | BASF AKTIENGSELLSCHAFT (DE) | 1990-08-28 | — | — | US | disclosed |
| US-4859232-A | Substituted-aryl cyclopropanecarbonitriles and derivatives thereof as herbicide antidotes | MONSANTO COMPANY (US) | 1989-08-22 | — | — | US | disclosed |
| EP-0310954-A1 | Ortho-substituted carboxylic acid benzyl esters and fungicides containing these compounds | BASF Aktiengesellschaft (DE) | 1989-04-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077356-A1 | Nonsteroidal antiinflammatory agents | PTGS1, PTGES2, PTGES | ADRA1A 471/4885ADRA1D 663/4885ADRA1B 754/4885 |
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | VCAM1, ICAM1, SELE | ADRA1A 898/4885ADRA1D 1029/4885ADRA1B 1123/4885 |
| US-20040254249-A1 | Nonsteroidal antiinflammatory agents | PTGS1, PTGER1, PTGES2 | ADRA1A 473/4885ADRA1D 557/4885ADRA1B 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.