Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22963141 | 1.00 | KDM4E (0.37) | KDM4EALDH1A1GBA1HTTTP53 | |
| SCHEMBL25512781 | 0.89 | HTT (0.37) | KDM4EALDH1A1GBA1HTTTP53 | |
| SCHEMBL25118180 | 0.87 | HRH2 (0.38) | KDM4EALDH1A1GBA1HTT | |
| SCHEMBL22963144 | 0.87 | GBA1 (0.38) | KDM4EALDH1A1GBA1HTTTP53 | |
| SCHEMBL23100560 | 0.87 | KDM4E (0.36) | KDM4EALDH1A1HTTTP53SMN1; SMN2 | |
| SCHEMBL26501022 | 0.87 | PIK3CD (0.39) | KDM4EALDH1A1HTTHTR7HTR1A | |
| SCHEMBL24060966 | 0.86 | ALDH1A1 (0.45) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL25075206 | 0.85 | MAOB (0.38) | KDM4EALDH1A1HTTHTR7 | |
| SCHEMBL12225624 | 0.85 | HTR1A (0.47) | KDM4EALDH1A1GBA1TP53SMN1; SMN2 | |
| SCHEMBL24847753 | 0.85 | ALDH1A1 (0.45) | KDM4EALDH1A1GBA1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019060742-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC (US) | 2019-03-28 | — | — | WO | disclosed |