Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | RECQL | P46063 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20855723 | 1.00 | ALOX15 (0.46) | ALOX15GABRA1GABRB1HPGDMAPT | |
| Hydrochloric Acid SCHEMBL31733717 | 0.98 | ALOX15 (0.45) | ALOX15GABRA1GABRB1HPGDMAPT | |
| SCHEMBL24838388 | 0.83 | ALOX15 (0.41) | ALOX15GABRA1GABRB1HPGDMAPT | |
| SCHEMBL282835 | 0.83 | GABRA1 (0.58) | ALOX15GABRA1GABRB1HPGDMAPT | |
| SCHEMBL31182212 | 0.83 | GABRA1 (0.58) | ALOX15GABRA1GABRB1HPGDMAPT | |
| SCHEMBL2984801 | 0.81 | ALOX15 (0.48) | ALOX15GABRA1GABRB1HPGDMAPT | |
| SCHEMBL6273718 | 0.79 | ALOX15 (0.46) | ALOX15GABRA1GABRB1HPGDMAPT | |
| SCHEMBL22499940 | 0.78 | TDP1 (0.53) | ALOX15GABRA1HPGDMAPTKDM4E | |
| SCHEMBL4368200 | 0.78 | LMNA (0.45) | ALOX15GABRA1MAPTKDM4ETDP1 | |
| SCHEMBL31485748 | 0.78 | LMNA (0.45) | ALOX15GABRA1MAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |
| WO-2019063748-A1 | ROR-GAMMA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-04 | — | — | WO | disclosed |