Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.31 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25450 | 0.78 | — | — | |
| SCHEMBL25418259 | 0.78 | ATAD2 (0.60) | ATAD2UBE2NTP53KDM3BKMT2A | |
| Thiouracil SCHEMBL22345877 | 0.77 | TP53 (0.63) | TP53DYRK1ABLM | |
| SCHEMBL28216801 | 0.76 | ATAD2 (0.58) | ATAD2UBE2NTP53KDM3BKMT2A | |
| SCHEMBL20718 | 0.76 | — | — | |
| Thiouracil SCHEMBL4958659 | 0.75 | TP53 (0.66) | ATAD2UBE2NTP53KDM3BKMT2A | |
| SCHEMBL11114659 | 0.74 | — | — | |
| Thymine SCHEMBL2476233 | 0.74 | ATAD2 (0.58) | ATAD2KMT2ADYRK1ANOS3NOS1 | |
| Thymine SCHEMBL536790 | 0.74 | ATAD2 (0.58) | ATAD2KMT2ADYRK1ANOS3NOS1 | |
| Thymine SCHEMBL29232704 | 0.71 | ATAD2 (0.76) | ATAD2UBE2NKDM3BKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020197330-A1 | COMPOSITION FOR TREATING HEMOPHILIA BY MEANS OF BLOOD COAGULATION FACTOR VIII GENE INVERSION CORRECTION | 주식회사 툴젠 | 2020-10-01 | — | — | WO | disclosed |
| US-20200263204-A1 | COMPOSITION FOR TREATING HEMOPHILIA A BY CRISPR/CAS SYSTEM OF REVERTING FVIII GENE INVERSION | TOOLGEN INC (KR) | 2020-08-20 | — | — | US | disclosed |
| EP-3690046-A2 | COMPOSITION FOR TREATMENT OF HEMOPHILIA, COMPRISING CRISPR/CAS SYSTEM HAVING COAGULATION FACTOR VIII GENE INVERSION CORRECTION POTENTIAL | Toolgen Incorporated (KR) | 2020-08-05 | — | — | EP | disclosed |
| WO-2019066518-A2 | COMPOSITION FOR TREATMENT OF HEMOPHILIA, COMPRISING CRISPR/CAS SYSTEM HAVING COAGULATION FACTOR VIII GENE INVERSION CORRECTION POTENTIAL | 주식회사 툴젠 | 2019-04-04 | — | — | WO | disclosed |