Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15052202 | 0.81 | KDM4E (0.49) | BRD4ALDH1A1HTTHSD17B10EPHX2 | |
| SCHEMBL8618469 | 0.78 | EPHX2 (0.47) | BRD4ALDH1A1HTTHSD17B10EPHX2 | |
| SCHEMBL1072522 | 0.75 | BRD4 (0.49) | BRD4ALDH1A1HTTHSD17B10EPHX2 | |
| SCHEMBL5672302 | 0.75 | EPHX2 (0.56) | ALDH1A1HTTHSD17B10EPHX2KMT2A | |
| SCHEMBL15052471 | 0.74 | CYP3A4 (0.51) | BRD4ALDH1A1HTTHSD17B10EPHX2 | |
| SCHEMBL19375492 | 0.72 | KMT2A (0.40) | BRD4ALDH1A1HTTHSD17B10EPHX2 | |
| SCHEMBL15052302 | 0.72 | KMT2A (0.56) | BRD4EPHX2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11883625 | 0.70 | HTT (0.50) | ALDH1A1HTTHSD17B10KDM4ELMNA | |
| SCHEMBL30002855 | 0.68 | ALDH1A1 (0.62) | ALDH1A1HTTHSD17B10EPHX2KMT2A | |
| SCHEMBL1332997 | 0.65 | ALDH1A1 (1.00) | ALDH1A1HTTHSD17B10EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163900-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163900-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-09 | — | — | US | disclosed |
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-09 | — | — | US | disclosed |
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-09 | — | — | US | disclosed |
| US-7750149-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750149-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750149-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1879872-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006110198-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229448-A1 | Seven-membered heterocyclic carbenes and their metal complexes | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | CYCS, COG7, SOD1 | BRD4 1230/4885ALDH1A1 1675/4885HTT 4201/4885 |
| US-20060229448-A1 | Seven-membered heterocyclic carbenes and their metal complexes | CYCS, COG7, SOD1 | BRD4 1230/4885ALDH1A1 1675/4885HTT 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.