Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TNKS | O95271 | 2/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11919912 | 0.85 | TNKS2 (0.58) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL20869674 | 0.82 | HSD17B10 (0.56) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL11919929 | 0.82 | NPSR1 (0.69) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL15709070 | 0.82 | ALDH1A1 (0.64) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL13048293 | 0.80 | ALDH1A1 (0.55) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL16486369 | 0.76 | TP53 (0.86) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL28313035 | 0.74 | MAPK13 (0.53) | TSHRALDH1A1LMNAHTTHSD17B10 | |
| SCHEMBL20869724 | 0.74 | PTK2 (0.47) | TSHRALDH1A1MAPTNPSR1TP53 | |
| SCHEMBL16790694 | 0.74 | TP53 (1.00) | ALDH1A1MAPTNPSR1TP53LMNA | |
| SCHEMBL16486486 | 0.74 | TP53 (0.72) | TSHRALDH1A1MAPTTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190099453-A1 | MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE | HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE) | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190099453-A1 | MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE | PYGL, HNF4A, ATF1 | TSHR 3778/4885ALDH1A1 1437/4885MAPT 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.