Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | USP4 | Q13107 | 1/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PAM | P19021 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6937307 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1TSHRKMT2AMEN1 | |
| SCHEMBL20673370 | 0.82 | ALDH1A1 (0.50) | SMN1; SMN2L3MBTL1TDP1TSHRKMT2A | |
| SCHEMBL26315892 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL22499185 | 0.80 | TDP1 (0.58) | SMN1; SMN2L3MBTL1TDP1TSHRKMT2A | |
| SCHEMBL16217874 | 0.79 | ALDH1A1 (0.50) | SMN1; SMN2L3MBTL1TDP1TSHRKMT2A | |
| SCHEMBL4953772 | 0.79 | KMT2A (0.44) | TSHRKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL25495837 | 0.77 | KMT2A (0.43) | TSHRKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL21049231 | 0.77 | KMT2A (0.43) | TSHRKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL522462 | 0.77 | KMT2A (0.43) | TSHRKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL31409726 | 0.76 | KMT2A (0.41) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210009580-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2021-01-14 | — | — | US | disclosed |
| US-10815228-B2 | Aztreonam derivatives and uses thereof | ARIXA PHARMACEUTICALS, INC. (US) | 2020-10-27 | — | — | US | disclosed |
| US-20190211006-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2019-07-11 | — | — | US | disclosed |
| US-10280161-B2 | Aztreonam derivatives and uses thereof | ARIXA PHARMACEUTICALS, INC. (US) | 2019-05-07 | — | — | US | disclosed |
| WO-2019070595-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
| US-20190100516-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280161-B2 | Aztreonam derivatives and uses thereof | MGAM, ABCG2, SI | SMN1; SMN2 3921/4885L3MBTL1 2241/4885TDP1 2196/4885 |
| US-20190211006-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | SMN1; SMN2 3921/4885L3MBTL1 2241/4885TDP1 2196/4885 |
| US-20190100516-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | SMN1; SMN2 3921/4885L3MBTL1 2241/4885TDP1 2196/4885 |
| US-10815228-B2 | Aztreonam derivatives and uses thereof | MGAM, ABCG2, SI | SMN1; SMN2 3921/4885L3MBTL1 2241/4885TDP1 2196/4885 |
| US-20210009580-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | SMN1; SMN2 3921/4885L3MBTL1 2241/4885TDP1 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.