Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21158528 | 1.00 | GBA1 (0.41) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL11344678 | 0.98 | ALDH1A1 (0.40) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL31293551 | 0.92 | L3MBTL1 (0.36) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL28489580 | 0.75 | GAA (0.50) | FAAHALDH1A1GAAMAPTTHRB | |
| SCHEMBL8803997 | 0.71 | PLA2G2A (0.47) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL4860823 | 0.70 | NAAA (0.54) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL8512828 | 0.70 | NAAA (0.54) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL9250191 | 0.70 | NAAA (0.54) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL419534 | 0.70 | NAAA (0.54) | GBA1PTGS1PTGS2MGLLFAAH | |
| SCHEMBL14184720 | 0.70 | NAAA (0.54) | GBA1PTGS1PTGS2MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180500-B2 | Derivatives of relebactam and uses thereof | ARIXA PHARMACEUTICALS, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200102307-A1 | DERIVATIVES OF RELEBACTAM AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. (US) | 2020-04-02 | — | — | US | disclosed |
| US-20190100516-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | ARIXA PHARMACEUTICALS, INC. | 2019-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100516-A1 | AZTREONAM DERIVATIVES AND USES THEREOF | MGAM, ABCG2, SI | GBA1 1382/4885PTGS1 4151/4885PTGS2 4118/4885 |
| US-20200102307-A1 | DERIVATIVES OF RELEBACTAM AND USES THEREOF | NRDC, MRPL19, MRPL12 | GBA1 766/4885PTGS1 4579/4885PTGS2 4532/4885 |
| US-11180500-B2 | Derivatives of relebactam and uses thereof | NRDC, MRPL19, MRPL12 | GBA1 766/4885PTGS1 4579/4885PTGS2 4532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.