Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31389266 | 0.83 | ALOX15 (0.55) | NOTUMLMNAHPGDMAPTTP53 | |
| SCHEMBL6079903 | 0.82 | ALDH1A1 (0.44) | NOTUMLMNAHPGDMAPTTP53 | |
| SCHEMBL31389313 | 0.81 | ALOX15 (0.47) | MAPTTP53SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL31389249 | 0.81 | ALOX15 (0.47) | MAPTTP53SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL17769171 | 0.81 | LMNA (0.50) | NOTUMLMNAHPGDMAPTTP53 | |
| SCHEMBL31389289 | 0.81 | MAPT (0.58) | LMNAMAPTTP53TDP1SMPD1 | |
| SCHEMBL20877162 | 0.80 | TP53 (0.47) | NOTUMLMNAHPGDMAPTTP53 | |
| SCHEMBL9452249 | 0.80 | NOTUM (0.51) | NOTUMLMNAHPGDMAPTTDP1 | |
| SCHEMBL6079964 | 0.78 | SMN1; SMN2 (0.44) | NOTUMLMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL6080412 | 0.78 | LMNA (0.47) | NOTUMLMNAHPGDSMN1; SMN2SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019070742-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | SIDECAR THERAPEUTICS, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
| WO-2019070742-A1 | APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS | SIDECAR THERAPEUTICS, INC. (US) | 2019-04-11 | — | — | WO | disclosed |