Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10826205 | 0.82 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1SMN1; SMN2GLA | |
| SCHEMBL22174752 | 0.80 | BCHE (0.46) | CA12CA9ALOX5APFEN1 | |
| SCHEMBL29403604 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2GLACYP3A4HSD17B10 | |
| SCHEMBL2081651 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2GLACYP3A4HSD17B10 | |
| SCHEMBL20929322 | 0.78 | MAPT (0.42) | HSD17B10KDM4ENAMPTGABRPGABRD | |
| SCHEMBL5694416 | 0.78 | MAOA (0.43) | ALDH1A1SMN1; SMN2CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL18779716 | 0.76 | KCNH3 (0.40) | ALDH1A1SMN1; SMN2KDM4ENAMPTCA12 | |
| SCHEMBL8535693 | 0.76 | KDM4E (0.59) | MTNR1AMTNR1BALDH1A1SMN1; SMN2GLA | |
| SCHEMBL171693 | 0.76 | MAPT (0.65) | MTNR1AMTNR1BALDH1A1SMN1; SMN2GLA | |
| Sulfuric Acid SCHEMBL11083725 | 0.76 | PKM (0.47) | MTNR1AMTNR1BALDH1A1SMN1; SMN2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10251893-B2 | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators | NOVARTIS AG (CH) | 2019-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10251893-B2 | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as Wnt signaling modulators | WNT1, CTNNB1, CTNNA1 | MTNR1A 333/4885MTNR1B 658/4885ALDH1A1 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.