Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12850061 | 0.89 | HDAC1 (1.00) | HDAC1HDAC6KCNH2AGTR1AGTR2 | |
| SCHEMBL15705709 | 0.89 | HDAC1 (0.84) | HDAC1HDAC6KCNH2AGTR1AGTR2 | |
| SCHEMBL12472634 | 0.85 | HDAC1 (0.77) | HDAC1HDAC6KCNH2AGTR1AGTR2 | |
| SCHEMBL9518750 | 0.81 | HDAC1 (0.69) | HDAC1HDAC6AGTR1AGTR2MAPT | |
| SCHEMBL9518397 | 0.74 | RAB9A (0.67) | HDAC1HDAC6KCNH2AGTR1AGTR2 | |
| SCHEMBL9518580 | 0.74 | MEN1 (0.61) | HDAC1HDAC6AGTR1AGTR2MAPT | |
| SCHEMBL15643267 | 0.73 | KCNH2 (1.00) | HDAC1HDAC6KCNH2MAPTDRD2 | |
| SCHEMBL9192299 | 0.73 | AGTR1 (1.00) | AGTR1AGTR2PPARGPOLB | |
| SCHEMBL9201172 | 0.73 | DRD2 (0.78) | HDAC1HDAC6AGTR1AGTR2MAPT | |
| SCHEMBL12850472 | 0.72 | HDAC1 (1.00) | HDAC1HDAC6KCNH2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670733-B1 | N-HYDROXYBENZAMIDE DERIVATIVES AS HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV ILLINOIS (US) | 2019-04-10 | — | — | EP | disclosed |