Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 9/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19222267 | 0.89 | KEAP1 (0.41) | KEAP1CPB2NAMPTGRM2RET | |
| SCHEMBL74518 | 0.67 | KEAP1 (0.68) | KEAP1CPB2NAMPTRETDAO | |
| SCHEMBL18297160 | 0.66 | KEAP1 (0.62) | KEAP1CPB2NAMPTRETDAO | |
| SCHEMBL15882279 | 0.66 | KEAP1 (0.58) | KEAP1CPB2NAMPTRETDAO | |
| Ammonia Solution, Strong SCHEMBL28922912 | 0.66 | KEAP1 (0.66) | KEAP1CPB2NAMPTRETDAO | |
| SCHEMBL19222365 | 0.65 | KDM4E (0.52) | — | |
| SCHEMBL3701442 | 0.65 | PTGER1 (0.60) | — | |
| SCHEMBL6816963 | 0.64 | SGMS2 (0.57) | — | |
| SCHEMBL10514477 | 0.64 | KEAP1 (0.58) | KEAP1CPB2NAMPTRETDAO | |
| SCHEMBL29372807 | 0.64 | KEAP1 (0.58) | KEAP1CPB2NAMPTRETDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3202460-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2019-06-12 | — | — | EP | disclosed |
| EP-3106460-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2019-04-10 | — | — | EP | disclosed |