Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20886935 | 0.86 | KDM4E (0.67) | KMT2AMEN1TSHRKDM4EALDH1A1 | |
| SCHEMBL20886946 | 0.86 | TAS1R3 (0.47) | SHMT2KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL20886932 | 0.86 | POLB (0.55) | SHMT2KMT2ATSHRKDM4EALDH1A1 | |
| SCHEMBL20887172 | 0.82 | SHMT2 (0.58) | SHMT2KMT2AMEN1TSHRKDM4E | |
| SCHEMBL20887183 | 0.82 | SHMT2 (0.58) | SHMT2KMT2AMEN1TSHRKDM4E | |
| SCHEMBL20887185 | 0.82 | MAPT (0.58) | SHMT2KMT2AMEN1TSHRKDM4E | |
| SCHEMBL13366272 | 0.80 | RAB9A (0.64) | KMT2AMEN1TSHRKDM4EALDH1A1 | |
| SCHEMBL830750 | 0.79 | KDM4E (0.74) | SHMT2KMT2AMEN1TSHRKDM4E | |
| SCHEMBL6852418 | 0.77 | KDM4E (0.76) | KMT2AMEN1TSHRKDM4EALDH1A1 | |
| SCHEMBL30008966 | 0.76 | THRB (0.69) | KMT2AKDM4EALDH1A1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019071104-A1 | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF HYPERAMMONEMIA | CHILDREN'S NATIONAL MEDICAL CENTER (US) | 2019-04-11 | — | — | WO | disclosed |