SCHEMBL20908970

SCHEMBL20908970

COn1nnc2cc(I)ccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 4/20 0.35
HDAC4 P56524 4/20 0.35
HDAC1 Q13547 4/20 0.35
HDAC7 Q8WUI4 4/20 0.35
HDAC2 Q92769 4/20 0.35
HDAC10 Q969S8 4/20 0.35
HDAC11 Q96DB2 4/20 0.35
HDAC8 Q9BY41 4/20 0.35
HDAC6 Q9UBN7 4/20 0.35
HDAC9 Q9UKV0 4/20 0.35
HDAC5 Q9UQL6 4/20 0.35
TSHR P16473 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
HCAR3 P49019 6/20 0.33
APP P05067 5/20 0.33
MAPT P10636 1/20 0.32
AHR P35869 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13604188 0.80 KCNMA1 (0.42) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18911786 0.76 HCAR3 (0.54) RXFP1HCAR3MAPTAHRSMN1; SMN2
SCHEMBL798347 0.73 TSHR (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL30807488 0.72 NAMPT (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL16714023 0.68 ALDH1A1 (0.48) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL12204548 0.67 KCNMA1 (0.43) TSHRNPSR1RXFP1MAPTSMN1; SMN2
SCHEMBL28416063 0.66 MEN1 (0.33) NPSR1HCAR3MAPTHPGDKMT2A
SCHEMBL23619038 0.65 HCAR3 (0.38) HCAR3NPC1RAB9AKMT2A
SCHEMBL19041909 0.65 PKM (0.47) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18924514 0.65 HDAC3 (0.41) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3694836-B1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB SHANGHAI CO LTD (CN) 2022-06-15 EP disclosed
WO-2019072237-A1 PROCESS FOR PREPARING INTERMEDIATE OF ANTI-TUMOR DRUG NIRAPARIB AND INTERMEDIATE THEREOF ZAI LAB (SHANGHAI) CO., LTD. (CN) 2019-04-18 WO disclosed