SCHEMBL20913083

SCHEMBL20913083

O=C(NO)c1nc(Br)ccc1F

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 12/20 0.37
HDAC1 Q13547 11/20 0.37
HDAC8 Q9BY41 5/20 0.35
ATR Q13535 1/20 0.34
HDAC3 O15379 2/20 0.33
HDAC2 Q92769 2/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
IDO1 P14902 1/20 0.33
ALOX15 P16050 1/20 0.33
CA9 Q16790 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HSD17B10 Q99714 1/20 0.33
NCOR2 Q9Y618 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SMPD1 P17405 1/20 0.33
CTSA P10619 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1711432 0.80 ALDH1A1 (0.39) ATRALOX15MEN1KMT2A
SCHEMBL31586624 0.80 ALDH1A1 (0.39) ATRALOX15MEN1KMT2A
SCHEMBL20917216 0.78 DGAT1 (0.40) ATRIDO1MEN1KMT2A
SCHEMBL30139591 0.78 DGAT1 (0.40) ATRIDO1MEN1KMT2A
SCHEMBL30409470 0.78 PTGS2 (0.33) MEN1KMT2A
SCHEMBL1855234 0.78 PTGS2 (0.33) MEN1KMT2A
SCHEMBL31316470 0.78 NPSR1 (0.47) HSD17B10
SCHEMBL21383676 0.78 NPSR1 (0.47) HSD17B10
SCHEMBL14893685 0.77 KMT2A (0.48) MEN1KMT2A
SCHEMBL18512342 0.74 GSK3B (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3697769-B1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NAT RECH SCIENT (FR) 2023-02-15 EP claimed
US-11370772-B2 6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-06-28 US claimed
EP-3697769-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS Centre National De La Recherche Scientifique (FR) 2020-08-26 EP claimed
US-20200255399-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS UNIVERSITÉ DE STRASBOURG (50%) (FR) 2020-08-13 US claimed
WO-2019076986-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-25 WO claimed
EP-3473618-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-24 EP claimed
EP-3697769-B1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NAT RECH SCIENT (FR) 2023-02-15 EP disclosed
EP-3697769-B1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NAT RECH SCIENT (FR) 2023-02-15 EP disclosed
US-11370772-B2 6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-06-28 US disclosed
US-11370772-B2 6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2022-06-28 US disclosed
EP-3697769-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS Centre National De La Recherche Scientifique (FR) 2020-08-26 EP disclosed
US-20200255399-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS UNIVERSITÉ DE STRASBOURG (50%) (FR) 2020-08-13 US disclosed
US-20200255399-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS UNIVERSITÉ DE STRASBOURG (50%) (FR) 2020-08-13 US disclosed
WO-2019076986-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-25 WO disclosed
WO-2019076986-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-25 WO disclosed
EP-3473618-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-24 EP disclosed
EP-3473618-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2019-04-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200255399-A1 6-SUBSTITUTED 3-FLUORO-2-PYRIDINALDOXIME, 3-FLUORO-2-PYRIDINE HYDROXAMIC ACID, AND 3-FLUORO-2-PYRIDINAMIDOXIME SCAFFOLDS PNPO, ACHE, PSEN2 HDAC6 3045/4885HDAC1 2262/4885HDAC8 4708/4885
US-11370772-B2 6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds PNPO, ACHE, PSEN2 HDAC6 3045/4885HDAC1 2262/4885HDAC8 4708/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.