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Flunisolide

Flunisolide

SCHEMBL9987242

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@]12F

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Flunisolide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.61
▸ CYP3A4 P08684 10/20 0.61
▸ LMNA P02545 7/20 0.61
▸ PGR P06401 7/20 0.61
▸ HIF1A Q16665 7/20 0.61
▸ HSD17B10 Q99714 5/20 0.61
▸ ABCB11 O95342 2/20 0.61
▸ KDM4E B2RXH2 2/20 0.61
▸ CYP2C19 P33261 1/20 0.61
▸ NR1I2 O75469 1/20 0.61
▸ HTR1A P08908 1/20 0.61
▸ ADRA2A P08913 1/20 0.61
▸ ADRA1A P35348 1/20 0.61
▸ AR P10275 4/20 0.56
▸ NFKB1 P19838 4/20 0.56
▸ TSHR P16473 2/20 0.56
▸ MAPT P10636 2/20 0.56
▸ PMP22 Q01453 2/20 0.56
▸ BLM P54132 2/20 0.56
▸ MEN1 O00255 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flunisolide SCHEMBL20915050 0.95 CYP3A4 (0.69) CYP3A4LMNANR3C1PGRHIF1A
Triamcinolone Acetonide SCHEMBL20915153 0.90 HIF1A (0.77) CYP3A4LMNANR3C1PGRHIF1A
Flunisolide SCHEMBL221433 0.87 PGR (0.73) CYP3A4LMNANR3C1PGRHIF1A
Desonide SCHEMBL11778722 0.87 CYP3A4 (0.73) CYP3A4LMNANR3C1PGRHIF1A
Desonide SCHEMBL2115498 0.86 CYP3A4 (0.75) CYP3A4LMNANR3C1PGRHIF1A
Fluocinolone Acetonide SCHEMBL5501859 0.85 HIF1A (0.77) CYP3A4LMNANR3C1PGRHIF1A
Triamcinolone Acetonide SCHEMBL28103100 0.84 CYP3A4 (0.87) CYP3A4LMNANR3C1PGRHIF1A
Triamcinolone Acetonide SCHEMBL1561091 0.83 HIF1A (0.89) CYP3A4LMNANR3C1PGRHIF1A
Triamcinolone Acetonide SCHEMBL1446089 0.83 HIF1A (0.89) CYP3A4LMNANR3C1PGRHIF1A
Fluocinolone Acetonide SCHEMBL2251974 0.82 NR3C1 (0.82) CYP3A4LMNANR3C1PGRHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10117974-B2 Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions ARROW INTERNATIONAL, INC. (US) 2018-11-06 — — US disclosed
US-10016532-B2 Non-fouling, anti-microbial, anti-thrombogenic graft compositions ARROW INTERNATIONAL, INC. (US) 2018-07-10 — — US disclosed
US-9096703-B2 Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions SEMPRUS BIOSCIENCES CORPORATION (US) 2015-08-04 — — US disclosed
US-20150056411-A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS TELEFLEX LIFE SCIENCES LIMITED (MT) 2015-02-26 — — US disclosed
US-20150045515-A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS TELEFLEX LIFE SCIENCES LIMITED (MT) 2015-02-12 — — US disclosed
US-20110305898-A1 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT 2011-12-15 — — US disclosed
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