Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20919699 | 0.83 | IDO1 (0.42) | ALDH1A1HDAC1IDO1LMNANPSR1 | |
| SCHEMBL20919670 | 0.83 | HDAC1 (0.43) | ALDH1A1HDAC1IDO1HDAC3HDAC7 | |
| SCHEMBL20919680 | 0.82 | ALDH1A1 (0.60) | ALDH1A1HDAC1IDO1LMNANPSR1 | |
| SCHEMBL9966266 | 0.82 | ALDH1A1 (0.62) | ALDH1A1HDAC1IDO1LMNANPSR1 | |
| SCHEMBL20919709 | 0.82 | IDO1 (0.41) | ALDH1A1HDAC1IDO1HDAC3HDAC7 | |
| SCHEMBL20919737 | 0.81 | FFAR2 (0.43) | ALDH1A1HDAC1IDO1LMNAHDAC3 | |
| SCHEMBL20919702 | 0.80 | FFAR2 (0.44) | ALDH1A1HDAC1IDO1LMNA | |
| SCHEMBL20919682 | 0.80 | HDAC1 (0.44) | ALDH1A1HDAC1IDO1HDAC3HDAC7 | |
| SCHEMBL20938113 | 0.80 | HDAC1 (0.44) | ALDH1A1HDAC1IDO1HDAC3HDAC7 | |
| SCHEMBL20919674 | 0.80 | IDO1 (0.40) | ALDH1A1HDAC1IDO1HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | claimed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | claimed |
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |