Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20919702 | 0.86 | FFAR2 (0.44) | ALDH1A1HTTHDAC1IDO1KDR | |
| SCHEMBL20938113 | 0.86 | HDAC1 (0.44) | ALDH1A1HTTHDAC1WNT3AIDO1 | |
| SCHEMBL20919682 | 0.86 | HDAC1 (0.44) | ALDH1A1HTTHDAC1KMT2AMEN1 | |
| SCHEMBL20919675 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HDAC1NPC1RAB9AMAPT | |
| SCHEMBL20919737 | 0.81 | FFAR2 (0.43) | ALDH1A1HDAC1WNT3AIDO1HDAC3 | |
| SCHEMBL20919712 | 0.79 | KDR (0.41) | IDO1KDR | |
| SCHEMBL20919674 | 0.79 | IDO1 (0.40) | ALDH1A1HDAC1IDO1HDAC3HDAC7 | |
| SCHEMBL20919699 | 0.79 | IDO1 (0.42) | ALDH1A1HDAC1IDO1HDAC3HDAC7 | |
| SCHEMBL20919670 | 0.79 | HDAC1 (0.43) | ALDH1A1HDAC1KMT2AMAPTIDO1 | |
| SCHEMBL9966254 | 0.78 | ALDH1A1 (0.66) | ALDH1A1HTTHDAC1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | claimed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | claimed |
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |