Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20919737 | 0.89 | FFAR2 (0.43) | FFAR2IDO1ALDH1A1HDAC1KDR | |
| SCHEMBL20938113 | 0.88 | HDAC1 (0.44) | IDO1ALDH1A1HDAC1KDRHTT | |
| SCHEMBL20919682 | 0.88 | HDAC1 (0.44) | IDO1ALDH1A1HDAC1KDRHTT | |
| SCHEMBL20919680 | 0.86 | ALDH1A1 (0.60) | IDO1ALDH1A1HDAC1KDRHTT | |
| SCHEMBL20919675 | 0.80 | ALDH1A1 (0.58) | IDO1ALDH1A1HDAC1LMNA | |
| SCHEMBL20919670 | 0.80 | HDAC1 (0.43) | IDO1ALDH1A1HDAC1KDR | |
| SCHEMBL20919699 | 0.80 | IDO1 (0.42) | IDO1ALDH1A1HDAC1KDRLMNA | |
| SCHEMBL20919701 | 0.79 | GRM5 (0.39) | FFAR2IDO1HDAC1KDR | |
| SCHEMBL20919712 | 0.78 | KDR (0.41) | IDO1KDR | |
| SCHEMBL20919674 | 0.78 | IDO1 (0.40) | IDO1ALDH1A1HDAC1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | claimed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | claimed |
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |