Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20919670 | 0.86 | HDAC1 (0.43) | IDO1CYP2C9HDAC1HDAC3HDAC7 | |
| SCHEMBL20919675 | 0.83 | ALDH1A1 (0.58) | IDO1HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL20919709 | 0.81 | IDO1 (0.41) | IDO1CYP2C9HDAC1HDAC3HDAC7 | |
| SCHEMBL20919737 | 0.80 | FFAR2 (0.43) | IDO1HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL20919736 | 0.80 | IDO1 (0.43) | IDO1CYP2C9HDAC1HDAC3HDAC7 | |
| SCHEMBL20919941 | 0.80 | HDAC1 (0.42) | IDO1CYP2C9HDAC1HDAC3HDAC7 | |
| SCHEMBL20919682 | 0.80 | HDAC1 (0.44) | IDO1HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL20938113 | 0.80 | HDAC1 (0.44) | IDO1HDAC1HDAC3HDAC7HDAC2 | |
| SCHEMBL20919702 | 0.80 | FFAR2 (0.44) | IDO1HDAC1KDRALDH1A1LMNA | |
| SCHEMBL20919680 | 0.79 | ALDH1A1 (0.60) | IDO1HDAC1HDAC3HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | claimed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | claimed |
| EP-3735410-A1 | PICOLINAMIDE COMPOUNDS | Tempest Therapeutics, Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| WO-2019079614-A1 | PICOLINAMIDE COMPOUNDS | TEMPEST THERAPEUTICS, INC. (US) | 2019-04-25 | — | — | WO | disclosed |