Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682483 | 0.86 | ERN1 (0.42) | ERN1POLBKDM4EAMY1AGRM2 | |
| SCHEMBL9530825 | 0.70 | PTGS1 (0.47) | POLBKDM4EAMY1APRKAB2PRKAG1 | |
| SCHEMBL9532209 | 0.69 | AMY1A (0.39) | ERN1POLBKDM4EAMY1APDE2A | |
| SCHEMBL19214428 | 0.68 | ALDH1A1 (0.55) | ERN1GRM2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1682501 | 0.68 | USP8 (0.37) | POLBKDM4EAMY1AGRM2PDE2A | |
| SCHEMBL10340365 | 0.68 | AMY1A (0.50) | ERN1AMY1AGRM2PRKAB2PRKAG1 | |
| SCHEMBL13874013 | 0.68 | THRB (0.41) | ERN1POLBKDM4EAMY1AGRM2 | |
| SCHEMBL9530823 | 0.68 | PTGS1 (0.38) | POLBKDM4EAMY1APDE2APRKAB2 | |
| SCHEMBL8471677 | 0.68 | AMY1A (0.38) | POLBKDM4EAMY1APDE2APRKAB2 | |
| SCHEMBL2551600 | 0.67 | ALDH1A1 (0.43) | ERN1KDM4EPDE2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486018-B1 | SUBSTITUTED PYRAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO PHARMA AB (SE) | 2019-04-24 | — | — | EP | disclosed |