Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | CDK9 | P50750 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714237 | 0.89 | SMN1; SMN2 (0.73) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL10401175 | 0.89 | SMN1; SMN2 (0.80) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL11238734 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL23069076 | 0.82 | NPC1 (0.65) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL9479624 | 0.82 | CASP3 (0.77) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL2887905 | 0.81 | NPC1 (0.70) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL8428905 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL17589369 | 0.80 | KMT2A (0.66) | SMN1; SMN2TP53EPHX1TSHREPHX2 | |
| SCHEMBL14029935 | 0.80 | ALDH1A1 (0.81) | SMN1; SMN2EPHX1TSHREPHX2NPC1 | |
| Hydrochloric Acid SCHEMBL11059549 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53EPHX1TSHREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10946023-B2 | Therapeutically active compounds and their methods of use | AGIOS PHARMACEUTICALS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190117661-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | SERVIER PHARMACEUTICALS LLC | 2019-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117661-A1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | MCL1, TP53, BRDT | SMN1; SMN2 568/4885TP53 2/4885EPHX1 1953/4885 |
| US-10946023-B2 | Therapeutically active compounds and their methods of use | MCL1, TP53, BRDT | SMN1; SMN2 568/4885TP53 2/4885EPHX1 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.